Laurent Marsollier Selected Research

mycolactone

12/2021	Ketogenic Diet Impairment of Mycobacterium ulcerans Growth and Toxin Production and Enhancement of Host Response to Infection in an Experimental Mouse Model.
12/2021	Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone.
1/2019	Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters.
1/2019	Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls.
1/2018	The potent effect of mycolactone on lipid membranes.
1/2017	A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone.
3/2016	FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer.
6/2014	Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.
11/2009	Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.
8/2005	Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.

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Laurent Marsollier Research Topics

Disease

16	Buruli Ulcer 12/2021 - 04/2003
7	Infections 12/2021 - 08/2005
2	Skin Ulcer 12/2021 - 01/2019
2	Communicable Diseases (Infectious Diseases) 12/2021 - 01/2019
2	Pain (Aches) 01/2019 - 01/2017
2	Hypesthesia (Numbness) 01/2019 - 06/2014
2	Ulcer 01/2011 - 02/2007
2	Tuberculosis (Tuberculoses) 10/2009 - 09/2006
1	Neglected Diseases 01/2020
1	Nerve Degeneration 01/2019
1	Inflammation (Inflammations) 01/2018
1	Spontaneous Remission 03/2016
1	Wounds and Injuries (Trauma) 11/2011
1	Leprosy (Hansen's Disease) 04/2003

Drug/Important Bio-Agent (IBA)

10	mycolactoneIBA 12/2021 - 08/2005
5	PolyketidesIBA 01/2019 - 08/2008
4	mycolactone AIBA 01/2019 - 08/2008
3	Virulence Factors (Pathogenicity Factors)IBA 12/2021 - 11/2009
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2006
2	RNA (Ribonucleic Acid)IBA 12/2021 - 01/2017
2	VaccinesIBA 01/2020 - 07/2006
2	Analgesics (Analgesic Drugs)IBA 01/2019 - 01/2017
2	Rifampin (Rifampicin)FDA LinkGeneric 01/2011 - 04/2003
2	Immunoglobulin G (IgG)IBA 11/2010 - 02/2007
1	Protein Subunit VaccinesIBA 01/2020
1	AntigensIBA 01/2020
1	Interferon-gamma (Interferon, gamma)IBA 01/2020
1	Interleukin-2 (IL2)IBA 01/2020
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2019
1	LactonesIBA 01/2019
1	ExotoxinsIBA 01/2019
1	EndotoxinsIBA 01/2018
1	LipidsIBA 01/2018
1	Indicators and Reagents (Reagents)IBA 04/2015
1	AngiotensinsIBA 06/2014
1	Soaps (Soap)IBA 11/2011
1	Clarithromycin (Biaxin)FDA LinkGeneric 01/2011
1	Polyketide SynthasesIBA 11/2010
1	PropionatesIBA 11/2010
1	Secretory Immunoglobulin A (SIgA)IBA 11/2009
1	lipoarabinomannan (LAM)IBA 10/2009
1	arabinogalactanIBA 10/2009
1	Pharmaceutical PreparationsIBA 10/2009
1	Racemases and Epimerases (Epimerases and Racemases)IBA 10/2009
1	Arabinose (L-Arabinose)IBA 10/2009
1	Histidine (L-Histidine)FDA Link 09/2006
1	Protein Sorting Signals (Signal Peptide)IBA 09/2006
1	Arginine (L-Arginine)FDA Link 09/2006
1	beta Lactam AntibioticsIBA 09/2006
1	DNA VaccinesIBA 07/2006
1	Chemokine CXCL2IBA 08/2005
1	MacrolidesIBA 08/2005
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2005

Therapy/Procedure

2	Analgesia 01/2019 - 06/2014
1	Ketogenic Diet 12/2021
1	Subcutaneous Injections 01/2019
1	Drug Therapy (Chemotherapy) 01/2011